Quinolines and derivatives

Medchemexpress LLC SPP-86 | 1357349-91-7 | 99.9% | 277.32 | 100 MG

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SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM. It inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling, and also inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells. This compound is a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• Potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM.
• Inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling.
• Inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells.
• Click chemistry reagent, containing an alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.

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Medchemexpress LLC Sulfo-cyanine3 azide (potassium) | 95.3% | 736.94 | 1 MG

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Sulfo-cyanine3 azide potassium is an azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). It can be used for synthesis of fused tricyclic heterocycles, producing immunostimulatory agents. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups, or ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

• Azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm).
• Used for synthesis of fused tricyclic heterocycles, producing immunostimulatory agents.
• Contains an azide group.
• Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups.
• Undergoes ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

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Medchemexpress LLC Ethanesulfonic acid, 2-[(aminoiminomethyl)amino]- | 543-18-0 | 99.9% | 167.19 | 100 MG

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Guanidinoethyl sulfonate (Standard) is an analytical standard and an orally available, blood-brain permeable competitive inhibitor of taurine transporters. It acts as a competitive antagonist of glycine receptors (GlyR) (IC50=565 μM) and shows weak agonist/antagonist effects on GABAA receptors. It inhibits taurine transmembrane transport, blocks glycine-mediated chloride influx, and may regulate brain pH for neuroprotective effects, useful in studies of ischemic brain injury. It is applied in qualitative, quantitative, and methodological research experiments including HPLC, GC, and MS.

• Analytical standard for research
• Orally available and blood-brain permeable
• Inhibits taurine transporters
• Antagonizes glycine receptors
• Modulates GABAA receptors
• Blocks glycine-mediated chloride influx
• May offer neuroprotective effects
• Used in HPLC, GC, and MS applications

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Medchemexpress LLC 4h-1-Benzopyran-4-one, 6-[3-(4-morpholinyl)propyl]-2-thieno[3,2-c]pyridin-6-yl-, oxime, hydrochloride | 2133294-96-7 | 98.6% | 457.97 | 25 MG

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Foliglurax monohydrochloride is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 79 nM. It exhibits an antiparkinsonian effect and is for research use only.

• Highly selective and potent mGluR4 PAM.
• Brain-penetrant.
• Exhibits an antiparkinsonian effect.
• For research use only.
• Potentially revolutionizing mGlu4 receptor drug targeting in CNS disorders.

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eMolecules​ EMOLECULES INC

5000189349 2-METHYLPYRIDINE-4-CARBA 500MG

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eMolecules​ EMOLECULES INC

5000190342 1H-BENZIMADAZOLE-5-CARBO 250MG

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eMolecules​ TETRAHYDROFURAN-2-CARBAL 100MG

5000192165 TETRAHYDROFURAN-2-CARBAL 100MG

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eMolecules​ TETRAHYDRO-FURAN-2-CARBA 100MG

5000192181 TETRAHYDRO-FURAN-2-CARBA 100MG

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Medchemexpress LLC SULFO-SPP 1MG

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5000202014 SULFO-SPP 1MG

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eMolecules​ 2-ACETAMIDOTHIAZOLE-5-SULFO 1G